THE DEVELOPMENT OF AN EXTENDED WEIBULL MODEL WITH APPLICATIONS TO MEDICINE, INDUSTRY AND ACTUARIAL SCIENCES


Targeted therapy in NPM1-mutated AML: Knowns and unknowns

Acute myeloid leukemia (AML) is a heterogeneous disease characterized by malignant proliferation of myeloid hematopoietic stem/progenitor cells.NPM1 represents the most frequently mutated gene in AML and approximately 30% of AML cases carry NPM1 mutations.Mutated NPM1 result in the cytoplasmic localization Glass Chiller of NPM1 (NPM1c).NPM1c intera

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